I'm going to start this thread because I sometimes stumble upon some pretty inspirational videos on Youtube. Here's a recent one... It's a 2010 interview where Stephen Colbert interviews Neil deGrasse Tyson at the Montclair Kimberley Academy. Check it out! PS. Feel free to add any inspirational videos you find to this thread!
Here's another one - Steve Job's famous commencement speech at Stanford University - "How to live before you die"!